Rick Zieff

Spike (voice)

Kath Soucie

Tuffy (voice)

Jason Alexander

Rick (voice)

Grey DeLisle

Ginger (voice)

Rachael MacFarlane

Hildie (voice)

Joey D'Auria

Butch / Droopy (voice)

Cree Summer

Beatie (voice)

Gary Cole

Narrator (voice)

Rene Mujica

Newt (voice)

Sam Kwasman

Little Quacker (voice)

Simon Helberg

Napoleon (voice)

Tom Kenny

Dr. Bigby / Hamster (voice)