With the help of a woman doctor named Ayako, Black Jack attempts to reach England by riding in the Sky Hospital, a military aircraft that had been converted into a fully functioning clinic. While he is on board, a pack of rogue militants hijack the plane, interested in turning it back into a fighting craft. Though the passengers and crew of the plane resist the terrorists, one of them detonates a stun grenade in the cockpit. The pilots and one of the terrorists are badly injured by shrapnel generated by the grenade, and the plane itself begins losing fuel. Black Jack and the planes owner, Dr. White, are forced to try and save the lives of the injured people and safely land the damaged Sky Hospital.