Welcome to Monster Madness 2019!! Tony and James review a movie about man's worst friend: this film. Man's Best Friend is a 1993 American horror comedy film, directed and written by John Lafia. It stars Ally Sheedy and Lance Henriksen. It's messy when a genetically engineered dog escapes from the science facility where it was created. A family takes it in unaware of its deadly instincts which soon emerge. The scientist who created the dog tries to find it before its too late.