Dan, Erica and Jack are running late for work when they find a middle aged woman on the bonnet of Dan's car. After she is taken via ambulance to All Saints, it is soon discovered that her incoherence and her physical frailty are the result of Huntington's disease. In treating her and in talking with her daughter, Dan comes to an important decision about his own health. Charlotte, Erica and Jack treat a young man struggling to come to terms with what he has done to his body. On his first day back at work, Mike is thrown into the middle of a major trauma. Bart comes into the ED to announce that Ann-Maree died the night before. The ED is stunned to learn the news about Frank's sudden resignation.