The settlers at Jamestown, the first British colony in the New World, were looking for wealth and adventure. But within six months 80 of the original 100 arrivals were dead; 440 of the first 500 died within three years. Death came in sudden, brutal waves marked by severe bruising, weakness, wasting and madness. Did the men die of disease and starvation? Or is it more than a coincidence that the deadly outbreaks always seemed to strike just after the supply ships set sail? Clues from Europe and the recently rediscovered Jamestown site have led pathologist Frank Hancock to a radical new theory that implicates some unlikely suspects. (UK/PBS 55 min)