After extracting alien DNA from a sample found on an asteroid, Dr. Piranoid tries to gene-slam the entire planet with this alien DNA mixed with manta ray DNA. The Street Sharks are sent up to space, per the president's request and help, to not only stop Dr. Piranoid's gene slamming plan, but also defeat the alien monster that was released from the sample. They end up getting help from Dr. Terrence Morton (who ends up becoming Mantaman in order to help fight the alien.)